As a specialist supplier Fa. PURIMEX has a variety of modifications in the program. The synthons are either produced in our own building block synthesis or purchased from reputable suppliers. For the sake of clarity, the products are innucleosidic and non-nucleosidic divided modifications, wherein the nucleosidic further divided into u DNA. RNA and after the heterocyclic bases A, G, C, T, I and U are ordered. The classification is not always unambiguously possible. If in doubt, please look on the internet to the structure. The delivery quantities can not be guaranteed as they depend on the ability of the modified coupling device and the number of modifications within an oligonucleotide. As a rule, but the quantities given in single and double HPLC purification can be achieved.

Season prices (prices with "*")

With exotic - or unstable in solution modules, we are forced to set a scaled price. In the table only the lowest price is shown and provided with a "*". This price is valid if you order the module 5x or multiples thereof, in one order. If less than 5 Couplings / order be ordered, so the prices are calculated using the following formula:

Price / clutch = 5x Season Price / Number of couplings per order

 

Nucleosidic modifications

DNA modifications

2'-dA modifications

designation

Price [euro] / clutch

50 nmol

200 nmol

1000 nmol

2'-dA-5'-amidite

12

15

23

2-amino-2'-dA

52 *

65 *

98 *

8-amino-2'-dA

104 *

130 *

195 *

2-amino-2'-dPurin

44 *

55 *

83 *

8-bromo-2'-dA

40 *

50 *

75 *

3-deaza-2'-dA

104 *

130 *

195 *

7-deaza-2'-dA

104 *

130 *

195 *

7-deaza-8-aza-2'-dA

120 *

150 *

225 *

N6-methyl-2'-dA

52 *

65 *

98 *

8-oxo-2'-dA

44 *

55 *

83 *

2'-dPurinribosid (nebularine)

34 *

43 *

65 *

*: Season Price (explanation see above.)

2'-dG modifications

designation

Price [euro] / clutch

50 nmol

200 nmol

1000 nmol

2'-5'-dG-amidite

12

15

23

8-amino-2'-dG

104 *

130 *

195 *

8-bromo-2'-dG

36 *

45 *

68 *

7-deaza-2'-dG

104 *

130 *

195 *

7-deaza-8-aza-2'-dG

104 *

130 *

195 *

2'-deoxy-isoG

52 *

65 *

98 *

N2 (C6 amino linker) -2'-dG

216 *

270 *

405 *

O6-methyl-2'-dG

36 *

45 *

68 *

8-O-methyl-2'-dG

104 *

130 *

195 *

8-oxo-2'-dG

104 *

130 *

195 *

6-thio-2'-dG

104 *

130 *

195 *

*: Season Price (explanation see above.)

2'-dC modifications

designation

Price [euro] / clutch

50 nmol

200 nmol

1000 nmol

2'-dC-5'-amidite

12

15

23

5-bromo-2'-dC

22 *

28 *

42 *

2'-deoxy-isoC

88 *

110 *

165 *

N3-ethyl-2'-dC

68 *

85 *

128 *

N4-ethyl-2'-dC

60 *

75 *

113 *

5-fluoro-2'-dC

60 *

75 *

113 *

5-hydroxy-2'-dC

96 *

120 *

180 *

5-hydroxymethyl-2'-dC

160 *

200 *

300 *

5-iodo-2'-dC

38 *

48 *

72 *

N3-methyl-2'-dC

68 *

85 *

128 *

5-methyl-2'-dC

22

28

42

*: Season Price (explanation see above.)

2'-dT modifications

designation

Price [euro] / clutch

50 nmol

200 nmol

1000 nmol

2'-dT-5'-amidite

12

15

23

(5 ') - amino-dT

48 *

60 *

90 *

N3-methyl-dT

76 *

95 *

143 *

O4-methyl-dT

44 *

55 *

83 *

2-thio-dT

104 *

130 *

195 *

4-thio-dT

88 *

110 *

165 *

4-triazolyl-dT

36 *

45 *

68 *

Thymidinglycol

104 *

130 *

195 *

*: Season Price (explanation see above.)

2'-dI modifications

designation

Price [euro] / clutch

50 nmol

200 nmol

1000 nmol

2'-dI

12

15

23

2'-dI CPG (3'-end)

22

28

42

2-fluoro-2'-dI

56 *

70 *

105 *

7-deaza-2'-dI

80 *

100 *

150 *

*: Season Price (explanation see above.)

2'-du-modifications

designation

Price [euro] / clutch

50 nmol

200 nmol

1000 nmol

2'-dU

12

15

23

2'-du CPG (3'-end)

28

35

53

5-bromo-2'-dU

22 *

28 *

42 *

2'-deoxy-pseudoU

104 *

130 *

195 *

5-fluoro-2'-dU

42 *

53 *

80 *

5-hydroxymethyl-2'-dU

64 *

80 *

120 *

5-iodo-2'-dU

35 *

44 *

66 *

2-thio-2'-dU

84 *

105 *

158 *

4-Thio-2'-dU

72 *

90 *

135 *

4-triazolyl-2'-dU

36 *

45 *

68 *

*: Season Price (explanation see above.)

RNA Modifications

rA-modifications

designation

Price [euro] / clutch

200 nmol

1000 nmol

2 ', 5'-rA

16

24

2'-fluoro-rA

27

41

2'-O-methyl-rA

5

8th

2'-O-methyl-2-aminopurine

127 *

191 *

2'-O-methyl-2,6-diaminopurine

105 *

158 *

2-Amino-rA

119 *

179 *

2-amino-purine

134 *

201 *

Arabino-rA

62 *

93 *

8-bromo-rA

49 *

74 *

7-deaza-rA

115 *

173 *

Purine riboside (nebularine)

139 *

209 *

CPG puromycin (3'-end)

62

93

*: Season Price (explanation see above.)

rG modifications

designation

Price [euro] / clutch

200 nmol

1000 nmol

2 ', 5'-rG

16

24

2'-fluoro-rG

27

41

2'-O-methyl-rG

5

8th

7-deaza-rG

127 *

191 *

Iso-rG

134 *

201 *

*: Season Price (explanation see above.)

rC modifications

designation

Price [euro] / clutch

200 nmol

1000 nmol

2 ', 5'-rC

16

24

2'-amino-rC

94 *

141 *

2'-fluoro-rC

9

14

2'-O-methyl-rC

5

8th

2'-O-methyl-5-methyl-rC

57 *

86 *

Arabino RC

55 *

83 *

5-bromo-rC

55 *

83 *

N4-ethyl-rC

99 *

149 *

5-iodo-rC

62 *

93 *

I so RC

134 *

201 *

5-methyl-rC

50 *

75 *

*: Season Price (explanation see above.)

rU-modifications

designation

Price [euro] / clutch

200 nmol

1000 nmol

2 ', 5'-rU

16

24

2'-amino-Ru

84 *

126 *

2'-fluoro-Ru

8th

12

2'-O-methyl-rU

5

8th

2'-O-methyl-5-bromo-rU

57 *

86 *

2'-O-methyl-5-fluoro-rU

129 *

194 *

2'-O-methyl-5-methyl-rU

50 *

75 *

5-bromo-rU

62 *

93 *

5-fluoro-rU

95 *

143 *

5-iodo-rU

62 *

93 *

N3-methyl-Ru

59 *

89 *

4-Thio-Ru

127 *

191 *

*: Season Price (explanation see above.)

RT modifications

designation

Price [euro] / clutch

200 nmol

1000 nmol

rThymidin

72 *

108 *

N3-methyl-RT

70 *

105 *

*: Season Price (explanation see above.)

RI modifications

designation

Price [euro] / clutch

200 nmol

1000 nmol

rInosin

13

20

2'-O-methyl-inosine

50 *

75 *

*: Season Price (explanation see above.)

Nonnucleosidic modifications

designation

Price [euro] / clutch

50 nmol

200 nmol

1000 nmol

Acridine (5 'end)

88 *

110 *

165 *

Acridine CPG (3'-end)

54

68

102

C6 amino linker (5'-end)

12

15

23

Aminolinker C6 CPG (3'-end)

23

29

44

Aminolinker C12 (5 'end)

32 *

40 *

60 *

Aminolinker C6-2'-dA

64 *

80 *

120 *

Aminolinker C6-2'-dG

136 *

170 *

255 *

Aminolinker C6-2'-dC

68

85

128

Aminolinker TEG N4-2'-dC

36 *

45 *

68 *

Aminolinker C6-2'-dC CPG

54

68

102

Aminolinker C6-2' dT

44

55

83

Aminolinker C6-2' dT CPG

45

57

86

Aminolinker C6-Ru

-

250

375

NHS-carboxy-C10 linker **

22

28

42

Cholesterol (5 'end)

82 *

103 *

155 *

Cholesterol CPG (3'-end)

52

65

98

Doubler, symmetrically

32 *

40 *

60 *

Doubler, asymmetrical

38 *

48 *

72 *

dSpacer (abasic site)

32

40

60

dSpacer CPG (abasic site)

86

108

162

Nitroindole

42 *

53 *

80 *

Nitroindole CPG (3'-end)

32

40

60

Nitropyrrole

42 *

53 *

80 *

Nitropyrrole CPG (3'-end)

32

40

60

Phosphate (5'-end)

12

15

23

Phosphate CPG (3'-end)

34

43

65

Psoralen C2 (5 'end)

52 *

65 *

98 *

Psoralen C6 (5 'end)

58 *

73 *

110 *

Psoralen CPG (3'-end)

52

65

98

Spacer C2 (ethanol)

30 *

38 *

57 *

Spacer C3 (propanol)

30 *

38 *

57 *

Spacer C4 (butanol)

30 *

38 *

57 *

Spacer C6 (hexanol)

30 *

38 *

57 *

Spacer C6 (triethyleneglycol)

28 *

35 *

53 *

Spacer C8 (tetraethylene)

30 *

38 *

57 *

Spacer C9 (nonanol)

28 *

35 *

53 *

Spacer C12 (dodecanol)

30 *

38 *

57 *

Spacer C12 (hexaethyleneglycol)

30 *

38 *

57 *

Thiol (5 'end) ***

24

30

45

Thiol CPG (3'-end) ***

36

45

68

*: Season Price (explanation see above.)

**: NHS-C10 linker only in conjunction with non-aqueous oxidation

***: Thiol linker technical reasons only in conjunction with double HPLC purification. With the simultaneous presence of a thiol and a 3-fold Aminolinkers HPLC is required

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