Phosphorothioate modified oligonucleotides are compounds in which a non-bridging oxygen atom of the internucleotide linkage has been replaced by sulfur. This results, inter alia, a significantly increased stability to nucleases. Important fields of application are:

  • As antisense samples for specific inhibition of gene expression
  • For the specific labeling of oligonucleotides
  • To block 3 ', 5'-exonucleases
  • For the investigation of RNA-protein interactions

The introduction of sulfur is carried out by oxidation with Beaucage reagent. The proportion of "oxo products" thus is very low. The price includes only the cost of the oxidation of the internucleotide bond. Cost base in the corresponding scale must be added.

For use in cell culture, we recommend a double HPLC purification followed by a sterile filtration (see purification).

designation

Price [euro] / clutch

50 nmol

200 nmol

1000 nmol

ASPTO oxidation DNA

0.80

1.00

1.50

ASPTO oxidation RNA

-

2.00

3.00

Larger standards on Anfrag

designation

Price [EUR]

Sterile filtration

10

set up ASPTO if order <10 bases

10

When using modules that are sensitive to water or jodempfindlich (z. B. NHS carboxy C10, thiomodifizierte bases) must be a non-aqueous oxidation at all other bases from the installation

designation

Price [euro] / clutch

50 nmol

200 nmol

1000 nmol

Organic oxidizing DNA

0.80

1.00

1.50

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